
Professor Timothy Salthouse of Virginia University found reasoning, speed of thought and spatial visualisation all decline in our late 20s.
Therapies designed to stall or reverse the ageing process may need to start much earlier, he said.
His seven-year study of 2,000 healthy people aged 18-60 is published in the journal Neurobiology of Aging.
To test mental agility, the study participants had to solve puzzles, recall words and story details and spot patterns in letters and symbols.