Amyloid precursor protein (APP) is a single transmembrane protein that undergoes sequential proteolysis to generate multiple peptides, including the amyloid beta peptide the major component of the senile plaques that are diagnostic hallmarks of Alzheimer disease (AD).
In 1984, Glenner and Wong purified APP derived from the twisted beta-pleated sheet fibrils present in cerebrovascular amyloidoses and in the amyloid plaques associated with Alzheimer disease1.
Structural characteristics
APP is a 110-130 kDa, transmembrane cell surface glycoprotein, which contains N and O, linked sugars. The largest region of the molecule is the extracellular domain. This domain contains a cysteine-rich region of about 200 amino acids and is at the N-terminus of the protein.
clipped from: bio-synthesis.blogspot.com