Smallpox (430 BC? - 1979):
Killed more than 300 million people worldwide in the 20th century alone, and most of the native inhabitants of the Americas
Spanish Flu (1918 - 1919):
Killed 50 to 100 million people worldwide in less than 2 years
In 1918 and 1919, the Spanish Flu pandemic killed more people than Hitler, nuclear weapons and all the terrorists of history combined.
Black Death (1340 - 1771):
Killed 75 million people worldwide
Malaria (1600 - today):
Kills about 2 million people per year
AIDS (1981 - today):
Killed 25 million people worldwide
Cholera (1817 - today):
8 pandemics
Typhus (430 BC? - today):
Killed 3 million people between 1918 and 1922 alone, and most of Napoleon's soldiers on Russia
Typhus is any one of several similar diseases caused by louse-borne bacteria.
Following the development of a vaccine during World War II epidemics occur only in Eastern Europe, the Middle East and parts of Africa.